Koagulacioni faktor XIIa
Koagulacioni faktor XIIa (EC 3.4.21.38, Hagemanov faktor (aktiviran), krvno-koagulacioni faktor XIIf, aktivirani beta krvno-koagulacioni faktor XII, prealbuminski aktivator, Hagemanov faktor beta-fragment, Hagemanov faktor fragment HFf, krvno-koagulacioni faktor XIIabeta, prekalikreinski aktivator, kalikreinogenski aktivator) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Koagulacioni faktor XIIa | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.38 | ||||||||
| CAS broj | 75216-42-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Selectivno razlaganje Arg-Ile veza u faktoru VII čime se formira faktor VIIa, i faktora XI čime se formira faktor XIa
Ovaj enzim takođe aktivira plazminogen i prokalikrein plazme.
Reference уреди
- ^ Fujikawa, K. & Davie, E.W. (1981). „Human factor XII (Hageman factor)”. Methods Enzymol. 80: 198—211. PMID 6918768.
- ^ Cho, K.; Tanaka, T.; Cook, R.R.; Kisiel, W.; Fujikawa, K.; Kurachi, K. & Powers, J.C. (1984). „Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates”. Biochemistry. 23: 644—650. PMID 6370301.
- ^ Que, B.G. & Davie, E.W. (1986). „Characterization of a cDNA coding for human factor XII (Hageman factor)”. Biochemistry. 25: 1525—1528. PMID 3011063.
- ^ Fujikawa, K. (1988). „Bovine Hageman factor and its fragments”. Methods Enzymol. 163: 54—68. PMID 3237089.
- ^ Silverberg, M. & Kaplan, A.P. (1988). „Human Hageman factor and its fragments”. Methods Enzymol. 163: 68—80. PMID 3237092.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Coagulation+factor+XIIa на US National Library of Medicine Medical Subject Headings (MeSH)
