Kortikosteroidna izomeraza bočnog lanaca
Kortikosteroidna izomeraza bočnog lanaca (EC 5.3.1.21) je enzim sa sistematskim imenom 11-dezoksikortikosteron aldoza-ketoza-izomeraza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Kortikosteroidna izomeraza bočnog lanaca | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.3.1.21 | ||||||||
| CAS broj | 75139-73-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 11-dezoksikortikosteron 20-hidroksi-3-oksopregn-4-en-21-al
Epimerizacija na C-20 i C-21 je verovatno katalizovana istim enzimom.
Reference уреди
- ^ Martin, K.O., Oh, S.-W., Lee, H.J. and Monder, C. (1977). „Studies on 21-3H-labeled corticosteroids: evidence for isomerization of the ketol side chain of 11-deoxycorticosterone by a hamster liver enzyme”. Biochemistry. 16: 3803—3809. PMID 901753.
- ^ Monder, C., Martin, K.O. and Bogumil, J. (1980). „Presence of epimerase activity in hamster liver corticosteroid side chain isomerase”. J. Biol. Chem. 255: 7192—7198. PMID 7391077.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Corticosteroid+side-chain-isomerase на US National Library of Medicine Medical Subject Headings (MeSH)
