L-lizin 6-oksidaza
L-lizin 6-oksidaza (EC 1.4.3.20, L-lizin-epsilon-oksidaza, Lod, LodA) je enzim sa sistematskim imenom L-lizin:kiseonik 6-oksidoreduktaza (deaminacija).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| L-lizin 6-oksidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.4.3.20 | ||||||||
| CAS broj | 1116448-48-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- L-lizin + O2 + H2O (S)-2-amino-6-oksoheksanoat +H2O2 + NH3
Ovaj enzim se razlikuje od EC 1.4.3.13, protein-lizin 6-oksidaza, po tome što koristi slobodan L-lizin umesto za protein-vezane forme. N2-acetil-L-lizin je takođe supstrat, dok N6-acetil-L-lizin nije.
Reference уреди
- ^ Lucas-Elío, P., Gómez, D., Solano, F. and Sanchez-Amat, A. (2006). „The antimicrobial activity of marinocine, synthesized by Marinomonas mediterranea, is due to hydrogen peroxide generated by its lysine oxidase activity”. J. Bacteriol. 188: 2493—2501. PMID 16547036.
- ^ Gómez, D., Lucas-Elío, P., Sanchez-Amat, A. and Solano, F. (2006). „A novel type of lysine oxidase: L-lysine-ε-oxidase”. Biochim. Biophys. Acta. 1764: 1577—1585. PMID 17030025.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- L-lysine+6-oxidase на US National Library of Medicine Medical Subject Headings (MeSH)
