Laktozilkeramid 1,3-N-acetil-b-D-glukozaminiltransferaza

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PMC	članci
PubMed	članci
NCBI	proteini

Laktozilkeramid 1,3-N-acetil-b-D-glukozaminiltransferaza
Laktozilkeramid 1,3-N-acetil-b-D-glukozaminiltransferaza
Identifikatori
EC broj	2.4.1.206
CAS broj	83682-80-8
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Laktozilkeramid 1,3-N-acetil-b-D-glukozaminiltransferaza (EC 2.4.1.206, LA2 sintaza, beta1->3-N-acetilglukozaminiltransferaza, uridin difosfoacetilglukozamin-laktozilkeramid beta-acetilglukozaminiltransferaza, laktozilkeramid beta-acetilglukozaminiltransferaza, UDP-N-acetil-D-glukozamin:D-galaktozil-1,4-beta-D-glukozilkeramid beta-1,3-acetilglukozaminiltransferaza, UDP-N-acetil-D-glukozamin:beta-D-galaktozil-(1->4)-beta-D-glukozil(1<->1)keramid 3-beta-N-acetilglukozaminiltransferaza) je enzim sa sistematskim imenom UDP-N-acetil-D-glukozamin:beta-D-galaktozil-(1->4)-beta-D-glukozil-(1<->1)-keramid 3-beta-N-acetilglukozaminiltransferaza.^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

UDP-N-acetil-D-glukozamin + beta-D-galaktozil-(1->4)-beta-D-glukozil-(1<->1)-keramid

\rightleftharpoons

UDP + N-acetil-beta-D-glukozaminil-(1->3)-beta-D-galaktozil-(1->4)-beta-D-glukozil-(1<->1)-keramid

Reference уреди

^ Gottfries, J., Percy, A.K., Maansson, J.-E., Fredman, P., Wilkstrand, C.J., Friedman, H.S., Bigner, D.D. and Svennerholm, L. (1991). „Glycolipids and glycosyltransferases in permanent cell lines established from human medulloblastomas”. Biochim. Biophys. Acta. 1081: 253—261. PMID 1825612.
^ Holmes, E.H., Hakomori, S. and Ostrander, G.K. (1987). „Synthesis of type 1 and 2 lacto series glycolipid antigens in human colonic adenocarcinoma and derived cell lines is due to activation of a normally unexpressed β1→3N-acetylglucosaminyltransferase”. J. Biol. Chem. 262: 15649—15658. PMID 2960671.
^ Percy, A.K., Gottfries, J., Vilbergsson, G., Maansson, J.E. and Svennerholm, J. (1991). „Glycosphingolipid glycosyltransferases in human fetal brain”. J. Neurochem. 56: 1461—1465. PMID 1901591.

Literatura уреди

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.

Spoljašnje veze уреди

Lactosylceramide+1,3-N-acetyl-beta-D-glucosaminyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Gottfries, J., Percy, A.K., Maansson, J.-E., Fredman, P., Wilkstrand, C.J., Friedman, H.S., Bigner, D.D. and Svennerholm, L. (1991). „Glycolipids and glycosyltransferases in permanent cell lines established from human medulloblastomas”. Biochim. Biophys. Acta. 1081: 253—261. PMID 1825612.

[2] Holmes, E.H., Hakomori, S. and Ostrander, G.K. (1987). „Synthesis of type 1 and 2 lacto series glycolipid antigens in human colonic adenocarcinoma and derived cell lines is due to activation of a normally unexpressed β1→3N-acetylglucosaminyltransferase”. J. Biol. Chem. 262: 15649—15658. PMID 2960671.

[3] Percy, A.K., Gottfries, J., Vilbergsson, G., Maansson, J.E. and Svennerholm, J. (1991). „Glycosphingolipid glycosyltransferases in human fetal brain”. J. Neurochem. 56: 1461—1465. PMID 1901591.

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