Laktozilkeramid a-2,6-N-sijaliltransferaza

Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Laktozilkeramid a-2,6-N-sijaliltransferaza
Laktozilkeramid a-2,6-N-sijaliltransferaza
Identifikatori
EC broj	2.4.99.11
CAS broj	55071-95-9
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Laktozilkeramid a-2,6-N-sijaliltransferaza (EC 2.4.99.11, citidin monofosfoacetilneuraminat-laktozilkeramid sijaliltransferaza, CMP-acetilneuraminat-laktozilkeramid-sijaliltransferaza, CMP-N-acetilneuraminska kiselina:laktozilkeramid sijaliltransferaza, CMP-sijalinska kiselina:laktozilkeramid sijaliltransferaza, CMP-N-acetilneuraminat:laktozilkeramid alfa-2,6-N-acetilneuraminiltransferaza, CMP-N-acetilneuraminat:beta-D-galaktozil-(1->4)-beta-D-glukozil(1<->1)keramid alfa-(2->6)-N-acetilneuraminiltransferaza) je enzim sa sistematskim imenom CMP-N-acetilneuraminat:beta-D-galaktozil-(1->4)-beta-D-glukozil-(1<->1)-keramid alfa-(2->6)-N-acetilneuraminiltransferaza.^[1]^[2] Ovaj enzim katalizuje sledeću hemijsku reakciju

CMP-N-acetilneuraminat + beta-D-galaktozil-(1->4)-beta-D-glukozil-(1<->1)-keramid

\rightleftharpoons

CMP + alfa-N-acetilneuraminil-(2->6)-beta-D-galaktozil-(1->4)-beta-D-glukozil-(1<->1)-keramid

Reference уреди

^ Albarracin, I., Lassaga, F.E. and Caputto, R. (1988). „Purification and characterization of an endogenous inhibitor of the sialyltransferase CMP-N-acetylneuraminate: lactosylceramide α2,6-N-acetylneuraminyltransferase (EC 2.4.99.-)”. Biochem. J. 254: 559—565. PMID 2460092.
^ Landa, C.A., Maccioni, H.J.F., Arce, A. and Caputto, R. (1977). „The biosynthesis of brain gangliosides. Separation of membranes with different ratios of ganglioside sialylating activity to gangliosides”. Biochem. J. 168: 325—332. PMID 606237.

Literatura уреди

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze уреди

Lactosylceramide+alpha-2,6-N-sialyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Albarracin, I., Lassaga, F.E. and Caputto, R. (1988). „Purification and characterization of an endogenous inhibitor of the sialyltransferase CMP-N-acetylneuraminate: lactosylceramide α2,6-N-acetylneuraminyltransferase (EC 2.4.99.-)”. Biochem. J. 254: 559—565. PMID 2460092.

[2] Landa, C.A., Maccioni, H.J.F., Arce, A. and Caputto, R. (1977). „The biosynthesis of brain gangliosides. Separation of membranes with different ratios of ganglioside sialylating activity to gangliosides”. Biochem. J. 168: 325—332. PMID 606237.

[1]

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