Legumain
Legumain (EC 3.4.22.34, asparaginska endopeptidaza, citvak, proteinaza B, hemoglobinaza, PRSC1 genski produkt (Homo sapiens), vicilinska peptidohidrolaza, endopeptidaza pasulja, vicilinska peptidohidrolaza) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Legumain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.34 | ||||||||
| CAS broj | 149371-18-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- Hidroliza proteina i malih molekulskih supstrata na -Asn-Xaa- vezama
Ovaj enzim je prisutan u mahunama metilja Schistosoma mansoni, i u lizozomima sisara.
Reference уреди
- ^ Hara-Nishimura, I. (1998). „Asparaginyl endopeptidase”. Ур.: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. Handbook of Proteolytic Enzymes. London: Academic Press. стр. 746—749.
- ^ Dalton, J.P. & Brindley, P.J. (1998). „Schistosome legumain”. Ур.: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. Handbook of Proteolytic Enzymes. London: Academic Press. стр. 749—754.
- ^ Chen, J.-M., Rawlings, N.D., Stevens, R.A.E. and Barrett, A.J. (1998). „Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases”. FEBS Lett. 441: 361—365. PMID 9891971.
Литература уреди
- Dalton, J.P. & Brindley, P.J. (1998). „Schistosome legumain”. Ур.: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. Handbook of Proteolytic Enzymes. London: Academic Press. стр. 749—754.
- Hara-Nishimura, I. (1998). „Asparaginyl endopeptidase”. Ур.: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. Handbook of Proteolytic Enzymes. London: Academic Press. стр. 746—749.
