Malonat-semialdehid dehidrogenaza (acetilacija)
Malonat-semialdehid dehidrogenaza (acetilacija) (EC 1.2.1.18, malonska semialdehidna oksidativna dekarboksilaza) je enzim sa sistematskim imenom 3-oksopropanoat:NAD(P)+ oksidoreduktaza (dekarboksilacija, KoA-acetilacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Malonat-semialdehid dehidrogenaza (acetilacija) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.2.1.18 | ||||||||
| CAS broj | 9028-97-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 3-oksopropanoat + KoA + NAD(P)+ acetil-KoA + CO2 + NAD(P)H
Reference уреди
- ^ Hayaishi, O., Nishizuka, Y., Tatibana, M., Takeshita, M. and Kuno, S. (1961). „Enzymatic studies on the metabolism of β-alanine”. J. Biol. Chem. 236: 781—790. PMID 13712439.
- ^ Jakoby, W.B. (1963). „Aldehyde dehydrogenases”. Ур.: Boyer, P.D., Lardy, H.; Myrb; auml; ck, K. The Enzymes. 7 (2nd изд.). New York: Academic Press. стр. 203—221.
- ^ Yamada, E.W. & Jakoby, W.B. (1960). „Aldehyde oxidation. V. Direct conversion of malonic semialdehyde to acetyl-coenzyme A”. J. Biol. Chem. 235: 589—594. PMID 13846369.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Malonate-semialdehyde+dehydrogenase+(acetylating) на US National Library of Medicine Medical Subject Headings (MeSH)
