Malonatna dekarboksilaza zavisna od biotina
Malonatna dekarboksilaza zavisna od biotina (EC 4.1.1.89, malonat dekarboksilaza (sa biotinom), malonat dekarboksilaza) je enzim sa sistematskim imenom malonat karboksilijaza (biotin-zavisna).[1][2][3][4][5][6][7] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Biotin-zavisna malonatna dekarboksilaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.1.1.89 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- malonat + H+ acetat + CO2
Pozanat su dva tipa malonatne dekarboksilaze. Oba su multienzimski kompleksi.
Reference уреди
- ^ Hilbi, H., Dehning, I., Schink, B. and Dimroth, P. (1992). „Malonate decarboxylase of Malonomonas rubra, a novel type of biotin-containing acetyl enzyme”. Eur. J. Biochem. 207: 117—123. PMID 1628643.
- ^ Hilbi, H. & Dimroth, P. (1994). „Purification and characterization of a cytoplasmic enzyme component of the Na+-activated malonate decarboxylase system of Malonomonas rubra: acetyl-S-acyl carrier protein: malonate acyl carrier protein-SH transferase”. Arch. Microbiol. 162: 48—56. PMID 18251085.
- ^ Berg, M., Hilbi, H. and Dimroth, P. (1996). „The acyl carrier protein of malonate decarboxylase of Malonomonas rubra contains 2′-(5"-phosphoribosyl)-3′-dephosphocoenzyme A as a prosthetic group”. Biochemistry. 35: 4689—4696. PMID 8664258.
- ^ Berg, M., Hilbi, H. and Dimroth, P. (1997). „Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function”. Eur. J. Biochem. 245: 103—115. PMID 9128730.
- ^ Micklefield, J., Harris, K.J., Gröger, S., Mocek, U., Hilbi, H., Dimroth, P. and Floss, H.G. (1995). „Stereochemical course of malonate decarboxylase in Malonomonas rubra has biotin decarboxylation with retention”. J. Am. Chem. Soc. 117: 1153—1154.
- ^ Kim, Y.S. (2002). „Malonate metabolism: biochemistry, molecular biology, physiology, and industrial application”. J. Biochem. Mol. Biol. 35: 443—451. PMID 12359084.
- ^ Dimroth, P. & Hilbi, H. (1997). „Enzymic and genetic basis for bacterial growth on malonate”. Mol. Microbiol. 25: 3—10. PMID 11902724.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Biotin-dependent+malonate+decarboxylase на US National Library of Medicine Medical Subject Headings (MeSH)
