Melilotat 3-monooksigenaza
Melilotat 3-monooksigenaza (EC 1.14.13.4, 2-hidroksifenilpropionatna hidroksilaza, melilotatna hidroksilaza, 2-hidroksifenilpropionska hidroksilaza, melilotinska hidroksilaza) je enzim sa sistematskim imenom 3-(2-hidroksifenil)propanoat,NADH:kiseonik oksidoreduktaza (3-hidroksilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Melilotat 3-monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.13.4 | ||||||||
| CAS broj | 37256-72-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 3-(2-hidroksifenil)propanoat + NADH + H+ + O2 3-(2,3-dihidroksifenil)propanoat + NAD+ + H2O
Ovaj enzim je flavoprotein (FAD).
Reference
уреди- ^ Levy, C.C. (1967). „Melilotate hydroxylase. Purification of the enzyme and the nature of the prosthetic group”. J. Biol. Chem. 242: 747—753. PMID 6017743.
- ^ Levy, C.C. & Frost, P. (1966). „The metabolism of coumarin by a microorganism. V. Melilotate hydroxylase”. J. Biol. Chem. 241: 997—1003. PMID 4285850.
- ^ Strickland, S. & Massey, V. (1973). „The purification and properties of the flavoprotein melilotate hydroxylase”. J. Biol. Chem. 248: 2944—2952. PMID 4348920.
- ^ Strickland, S. & Massey, V. (1973). „The mechanism of action of the flavoprotein melilotate hydroxylase”. J. Biol. Chem. 248: 2953—2962. PMID 4348921.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Melilotate+3-monooxygenase на US National Library of Medicine Medical Subject Headings (MeSH)
