Metilisani-DNK—(protein)-cistein S-metiltransferaza
Metilisani-DNK—(protein)-cistein S-metiltransferaza (EC 2.1.1.63, Methylated-DNA---(protein)-cysteine S-methyltransferase) je enzim sa sistematskim imenom DNK-6-O-metilguanin:(protein)-L-cistein S-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Metilisani-DNK—(protein)-cistein S-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.63 | ||||||||
| CAS broj | 77271-19-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- DNK (koja sadrži 6-O-metilguanin) + protein L-cistein DNK (bez 6-O-metilguanina) + protein S-metil-L-cistein
Ovaj protein učestvuje u popravci alkilisanog DNK. On deluje na alkilisani DNK (cf. EC 3.2.2.20, DNK-3-metiladenin glikozidaza I i EC 3.2.2.21, DNK-3-metiladenin glikozidaza II).
Reference
уреди- ^ Foote, R.S., Mitra, S. and Pal, B.C. (1980). „Demethylation of O6-methylguanine in a synthetic DNA polymer by an inducible activity in Escherichia coli”. Biochem. Biophys. Res. Commun. 97: 654—659. PMID 7008792.
- ^ Olsson, M. & Lindehl, T. (1980). „Repair of alkylated DNA in Escherichia coli. Methyl group transfer from O6-methylguanine to a protein cysteine residue”. J. Biol. Chem. 255: 10569—10571. PMID 7000780.
- ^ Pegg, A.E. & Byers, T.L. (1992). „Repair of DNA containing O6-alkylguanine”. FASEB J. 6: 2302—2310. PMID 1544541.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Methylated-DNA—(protein)-cysteine+S-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
