N,N'-diacetilegionaminat sintaza
(преусмерено са N,N'-diacetilegionaminatna sintaza)
N,N'-diacetilegionaminat sintaza (EC 2.5.1.101, neuB (gen), legI (gen)) je enzim sa sistematskim imenom fosfenolpiruvat:2,4-diacetamido-2,4,6-tridezoksi-alfa-D-mannopiranoza 1-(2-karboksi-2-oksoetil)transferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| N,N'-diacetilegionaminat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.5.1.101 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2,4-diacetamido-2,4,6-tridezoksi-alfa-D-manopiranoza + fosfenolpiruvat + H2O N,N'-diacetillegionaminat + fosfat
Za dejstvo ovog enzima je neophodan divalentni metalni jon, poput Mn2+. Enzim je izolovan iz bakterija Legionella pneumophila i Campylobacter jejuni, gde učestvuje u biosinteza legionaminske kiseline.
Reference уреди
- ^ Glaze, P.A., Watson, D.C., Young, N.M. and Tanner, M.E. (2008). „Biosynthesis of CMP-N,N′-diacetyllegionaminic acid from UDP-N,N′-diacetylbacillosamine in Legionella pneumophila”. Biochemistry. 47: 3272—3282. PMID 18275154.
- ^ Schoenhofen, I.C., Vinogradov, E., Whitfield, D.M., Brisson, J.R. and Logan, S.M. (2009). „The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors”. Glycobiology. 19: 715—725. PMID 19282391.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- N,N'-diacetyllegionaminate+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
