N-acetil-1-D-mio-inozitol-2-amino-2-dezoksi-alfa-D-glukopiranozidna deacetilaza
N-acetil-1-D-mio-inozitol-2-amino-2-dezoksi-alfa-D-glukopiranozidna deacetilaza (EC 3.5.1.103, MshB) je enzim sa sistematskim imenom 1-(2-acetamido-2-dezoksi-alfa-D-glukopiranosil)-1D-mio-inozitol acetilhidrolaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
N-acetil-1-D-mio-inozitol-2-amino-2-dezoksi-alfa-D-glukopiranozidna deacetilaza | |||||||||
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Identifikatori | |||||||||
EC broj | 3.5.1.103 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 1-(2-acetamido-2-dezoksi-alfa-D-glukopiranozil)-1D-mio-inozitol + H2O 1-(2-amino-2-dezoksi-alfa-D-glukopiranozid)-1D-mio-inozitol + acetat
Ovaj enzim posreduje reakcioni step koji ograničava brzinu sinteze mikotiola.
Reference уреди
- ^ Rawat, M., Kovacevic, S., Billman-Jacobe, H. and Av-Gay, Y. (2003). „Inactivation of mshB, a key gene in the mycothiol biosynthesis pathway in Mycobacterium smegmatis”. Microbiology. 149: 1341—1349. PMID 12724395.
- ^ Newton, G.L., Av-Gay, Y. and Fahey, R.C. (2000). „N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-α-D-glucopyranoside deacetylase (MshB) is a key enzyme in mycothiol biosynthesis”. J. Bacteriol. 182: 6958—6963. PMID 11092856.
- ^ Maynes, J.T., Garen, C., Cherney, M.M., Newton, G., Arad, D., Av-Gay, Y., Fahey, R.C. and James, M.N. (2003). „The crystal structure of 1-D-myo-inosityl 2-acetamido-2-deoxy-α-D-glucopyranoside deacetylase (MshB) from Mycobacterium tuberculosis reveals a zinc hydrolase with a lactate dehydrogenase fold”. J. Biol. Chem. 278: 47166—47170. PMID 12958317.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside+deacetylase на US National Library of Medicine Medical Subject Headings (MeSH)