N-acetilglukozaminil-difosfo-dekaprenol L-ramnoziltransferaza
N-acetilglukozaminil-difosfo-dekaprenol L-ramnoziltransferaza (EC 2.4.1.289, WbbL) je enzim sa sistematskim imenom dTDP-6-dezoksi-beta-L-manoza:N-acetil-alfa-D-glukozaminil-difosfo-trans,oktacis-dekaprenol 3-alfa-L-ramnoziltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| N-acetilglukozaminil-difosfo-dekaprenol L-ramnoziltransferaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 2.4.1.289 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- dTDP-6-dezoksi-beta-L-manoza + N-acetil-alfa-D-glukozaminil-difosfo-trans,oktacis-dekaprenol dTDP + alfa-L-ramnopiranozil-(1->3)-N-acetil-alfa-D-glukozaminil-difosfo-trans,oktacis-dekaprenol
Za dejstvo ovog enzima je neophodan Mn2+ ili Mg2+. On je izolovan iz Mycobakterija smegmatis i Mycobakterija tuberculosis.
Reference уреди
- ^ Mills, J.A., Motichka, K., Jucker, M., Wu, H.P., Uhlik, B.C., Stern, R.J., Scherman, M.S., Vissa, V.D., Pan, F., Kundu, M., Ma, Y.F. and McNeil, M. (2004). „Inactivation of the mycobacterial rhamnosyltransferase, which is needed for the formation of the arabinogalactan-peptidoglycan linker, leads to irreversible loss of viability”. J. Biol. Chem. 279: 43540—43546. PMID 15294902.
- ^ Grzegorzewicz, A.E., Ma, Y., Jones, V., Crick, D., Liav, A. and McNeil, M.R. (2008). „Development of a microtitre plate-based assay for lipid-linked glycosyltransferase products using the mycobacterial cell wall rhamnosyltransferase WbbL”. Microbiology. 154: 3724—3730. PMID 19047740.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- N-acetylglucosaminyl-diphospho-decaprenol+L-rhamnosyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
