N-acetilneuraminat sintaza
N-acetilneuraminat sintaza (EC 2.5.1.56, (NANA) kondenzujući enzim, N-acetilneuraminat piruvat-lijaza (piruvatna fosforilacija), NeuAc sintaza) je enzim sa sistematskim imenom fosfoenolpiruvat:N-acetil-D-manozamin C-(1-karboksivinil)transferaza (fosfatna hidroliza, formira 2-karboksi-2-oksoetil).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
N-acetilneuraminat sintaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.5.1.56 | ||||||||
CAS broj | 37290-66-7 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- fosfoenolpiruvat + N-acetil-D-manozamin + H 2O fosfat + N-acetilneuraminat
Reference
уреди- ^ Blacklow, R.S. & Warren, L. (1962). „Biosynthesis of sialic acids by Neisseria meningitidis”. J. Biol. Chem. 237: 3520—3526. PMID 13971393.
- ^ Komaki, E., Ohta, Y. and Tsukada, Y. (1997). „Purification and characterization of N-acetylneuraminate synthase from Escherichia coli K1-M12”. Biosci. Biotechnol. Biochem. 61: 2046—2050. PMID 9438985.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- N-acetylneuraminate+synthase на US National Library of Medicine Medical Subject Headings (MeSH)