NAD(P)H oksidaza (EC 1.6.3.1, THOX2, ThOX, dualna oksidaza, p138tox, tiroid NADPH oksidaza, tiroidna oksidaza, tiroidna oksidaza 2, NADPH oksidaza) je enzim sa sistematskim imenom NAD(P)H:kiseonik oksidoreduktaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

NAD(P)H oksidaza
Identifikatori
EC broj1.6.3.1
CAS broj77106-92-4
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum
NAD(P)H + H+ + O2 NAD(P)+ +H2O2

Za rad ovog enzima je neophodan FAD, hem i kalcijum.

Reference

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  1. ^ Moreno, J.C., Bikker, H., Kempers, M.J., van Trotsenburg, A.S., Baas, F., de Vijlder, J.J., Vulsma, T. and Ris-Stalpers, C. (2002). „Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism”. N. Engl. J. Med. 347: 95—102. PMID 12110737. 
  2. ^ De Deken, X., Wang, D., Dumont, J.E. and Miot, F. (2002). „Characterization of ThOX proteins as components of the thyroid H2O2-generating system”. Exp. Cell. 273: 187—196. PMID 11822874. 
  3. ^ De Deken, X., Wang, D., Many, M.C., Costagliola, S., Libert, F., Vassart, G., Dumont, J.E. and Miot, F. (2000). „Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family”. J. Biol. Chem. 275: 23227—23233. PMID 10806195. 
  4. ^ Dupuy, C., Ohayon, R., Valent, A., Noel-Hudson, M.S., Deme, D. and Virion, A. (1999). „Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cDNAs”. J. Biol. Chem. 274: 37265—37269. PMID 10601291. 
  5. ^ Leseney, A.M., Deme, D., Legue, O., Ohayon, R., Chanson, P., Sales, J.P., Pires de Carvalho, D., Dupuy, C. and Virion, A. (1999). „Biochemical characterization of a Ca2+/NAD(P)H-dependent H2O2 generator in human thyroid tissue”. Biochimie. 81: 373—380. PMID 10401672. 
  6. ^ Dupuy, C., Virion, A., Ohayon, R., Kaniewski, J., Deme, D. and Pommier, J. (1991). „Mechanism of hydrogen peroxide formation catalyzed by NADPH oxidase in thyroid plasma membrane”. J. Biol. Chem. 266: 3739—3743. PMID 1995628. 

Literatura

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Spoljašnje veze

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