Nervonska kiselina
Nervonska kiselina je mononezasićena omega-9 masna kiselina. Utvrđeno je da je nervonska kiselina važna u biosintezi mijelina nervnih ćelija.[5] Ona je prisutana u sfingolipidima bele materije ljudskog mozga.
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| Nazivi | |
|---|---|
| IUPAC naziv
(Z)-Tetrakoz-15-enoinska kiselina
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| Drugi nazivi
cis-15-Tetrakozenoinska kiselina
24:1 cis, delta 9 ili 24:1 omega 9 | |
| Identifikacija | |
3D model (Jmol)
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| ChEBI | |
| ChemSpider | |
| ECHA InfoCard | 100.108.655 |
| KEGG[2] | |
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| Svojstva | |
| C24H46O2 | |
| Molarna masa | 366,62 g/mol |
| Tačka topljenja | 42–43 °C |
Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa). | |
 verifikuj (šta je   ?)
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| Reference infokutije | |
Nervonska kiselina se koristi u tretmanu poremećaja uzrokovanih demijelinacijom, kao što su adrenoleukodistrofija i multipla skleroza gde postoji snižen nivo nervonske kiseline u sfingolipidima.[6]
Reference уреди
- ^ Nervonic acid at Sigma-Aldrich
- ^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003.
- ^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
- ^ US Patent 6664406[мртва веза], Nervonic acid derivatives, their preparation and use
- ^ WO/1996/005740[мртва веза], Nervonic Acid Compositions
Literatura уреди
- Appelqvist (1976) Lipids in Cruciferae. In: Vaughan JG, Macleod AJ (Eds), The biology and the Chemistry of Cruciferae. Academic Press, London, UK, pp. 221–277.
- Sargent JR, Coupland K, Wilson R (1994). Nervonic Acid and Demyelinating Disease. Medical Hypothesese 42, pp. 237–242.
