Plasmaniletanolamin desaturaza
Plasmaniletanolamin desaturaza (EC 1.14.99.19, alkilacilglicerofosfoetanolaminska desaturaza, alkilacilglicero-fosforiletanolaminska dehidrogenaza, dehidrogenaza, alkil-acilglicerofosforiletanolamin, 1-O-alkil-2-acil-sn-glicero-3-fosforiletanolaminska desaturaza, 1-O-alkil 2-acil-sn-glicero-3-fosforiletanolaminska desaturaza) je enzim sa sistematskim imenom O-1-alkil-2-acil-sn-glicero-3-fosfoetanolamin,vodonik-donor:kiseonik oksidoreduktaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju:
| Plasmaniletanolamin desaturaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.99.19 | ||||||||
| CAS broj | 39391-13-4 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- O-1-alkil-2-acil-sn-glicero-3-fosfoetanolamin + AH2 + O2 O-1-alk-1-enil-2-acil-sn-glicero-3-fosfoetanolamin + A + 2H2O
Za rad ovog enzima je neophodan NADPH ili NADH.
Reference уреди
- ^ Paltauf, F. & Holasek, A. (1973). „Enzymatic synthesis of plasmalogens. Characterization of the 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase from mucosa of hamster small intestine”. J. Biol. Chem. 248: 1609—1615. PMID 4144394.
- ^ Wykle, R.L., Blank, M.L., Malone, B. and Snyder, F. (1972). „Evidence for a mixed function oxidase in the biosynthesis of ethanolamine plasmalogens from 1-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine”. J. Biol. Chem. 247: 5442—5447. PMID 4403444.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Plasmanylethanolamine+desaturase на US National Library of Medicine Medical Subject Headings (MeSH)
