O-1238

O-1238
IUPAC ime
	(6aR)-3-[(Z)-6-azidoheks-2-enil]-6,6,9-trimetil-6a,7,10,10a-tetrahidrobenzo[c]hromen-1-ol
Identifikatori
ATC kod	none
PubChem	CID 10761489
Hemijski podaci
Formula	C22H29N3O2
Molarna masa	367,483 g/mol
	SMILES CC3=CCC2C(C)(C)Oc(c1C2C3)cc(cc1O)CC=CCCCN=N=N; ;

O-1238 je lek koji je kanabinoidni derivat. On se koristi u naučnim istraživanjima. O-1238 je parcijalni agonist kanabinoidnog receptora CB₁,^[1] sa maksimalnom stimulacijom od 58.3%^[2] i Ki vrednošću od 8,45 nM.^[3]

Reference уреди

^ Griffin, Graeme; Wray, Emma J.; Martin, Billy R.; Abood, Mary E. (1999). „Cannabinoid agonists and antagonists discriminated by receptor binding in rat cerebellum”. British Journal of Pharmacology. 128 (3): 684—688. PMC 1571656  . PMID 10516649. doi:10.1038/sj.bjp.0702806.
^ Griffin, Graeme; Wray, Emma J.; Rorrer, William K.; Crocker, Peter J.; Ryan, William J.; Saha, Bijali; Razdan, Raj K.; Martin, Billy R.; Abood, Mary E. (1999). „An investigation into the structural determinants of cannabinoid receptor ligand efficacy”. British Journal of Pharmacology. 126 (7): 1575—1584. PMC 1565939  . PMID 10323589. doi:10.1038/sj.bjp.0702469.
^ Ross, R. A.; Gibson, T. M.; Stevenson, L. A.; Saha, B.; Crocker, P.; Razdan, R. K.; Pertwee, R. G. (1999). „Structural determinants of the partial agonist-inverse agonist properties of 6'-azidohex-2'-yne-delta8-tetrahydrocannabinol at cannabinoid receptors”. British Journal of Pharmacology. 128 (3): 735—743. PMC 1571677  . PMID 10516656. doi:10.1038/sj.bjp.0702836.

Spoljašnje veze уреди

[1] Griffin, Graeme; Wray, Emma J.; Martin, Billy R.; Abood, Mary E. (1999). „Cannabinoid agonists and antagonists discriminated by receptor binding in rat cerebellum”. British Journal of Pharmacology. 128 (3): 684—688. PMC 1571656  . PMID 10516649. doi:10.1038/sj.bjp.0702806.

[2] Griffin, Graeme; Wray, Emma J.; Rorrer, William K.; Crocker, Peter J.; Ryan, William J.; Saha, Bijali; Razdan, Raj K.; Martin, Billy R.; Abood, Mary E. (1999). „An investigation into the structural determinants of cannabinoid receptor ligand efficacy”. British Journal of Pharmacology. 126 (7): 1575—1584. PMC 1565939  . PMID 10323589. doi:10.1038/sj.bjp.0702469.

[3] Ross, R. A.; Gibson, T. M.; Stevenson, L. A.; Saha, B.; Crocker, P.; Razdan, R. K.; Pertwee, R. G. (1999). „Structural determinants of the partial agonist-inverse agonist properties of 6'-azidohex-2'-yne-delta8-tetrahydrocannabinol at cannabinoid receptors”. British Journal of Pharmacology. 128 (3): 735—743. PMC 1571677  . PMID 10516656. doi:10.1038/sj.bjp.0702836.

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