O-fosfo-L-seril-tRNKSec:L-selenocisteinil-tRNK sintaza
(преусмерено са O-fosfo-L-seril-tRNKSec:L-selenocisteinil tRNK sintaza)
O-fosfo-L-seril-tRNKSec:L-selenocisteinil-tRNK sintaza (EC 2.9.1.2, MMPSepSecS, SepSecS, SLA/LP, O-fosfoseril-tRNK:selenocisteinil-tRNK sintaza, O-fosfo-L-seril-tRNK:L-selenocisteinil-tRNK sintaza) je enzim sa sistematskim imenom selenofosfat:O-fosfo-L-seril-tRNKSec selenijum transferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| O-fosfo-L-seril-tRNKSec:L-selenocisteinil-tRNK sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 2.9.1.2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- O-fosfo-L-seril-tRNKSec + selenofosfat L-selenocisteinil-tRNKSec + fosfat
Ovaj enzim je piridoksal-fosfatni protein.
Reference уреди
- ^ Palioura, S., Sherrer, R.L., Steitz, T.A., Soll, D. and Simonovic, M. (2009). „The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation”. Science. 325: 321—325. PMID 19608919.
- ^ Araiso, Y., Palioura, S., Ishitani, R., Sherrer, R.L., O'Donoghue, P., Yuan, J., Oshikane, H., Domae, N., Defranco, J., Soll, D. and Nureki, O. (2008). „Structural insights into RNA-dependent eukaryal and archaeal selenocysteine formation”. Nucleic Acids Res. 36: 1187—1199. PMID 18158303.
- ^ Aeby, E., Palioura, S., Pusnik, M., Marazzi, J., Lieberman, A., Ullu, E., Soll, D. and Schneider, A. (2009). „The canonical pathway for selenocysteine insertion is dispensable in Trypanosomes”. Proc. Natl. Acad. Sci. USA. 106: 5088—5092. PMID 19279205.
- ^ Yuan, J., Palioura, S., Salazar, J.C., Su, D., O'Donoghue, P., Hohn, M.J., Cardoso, A.M., Whitman, W.B. and Soll, D. (2006). „RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea”. Proc. Natl. Acad. Sci. USA. 103: 18923—18927. PMID 17142313.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
