Oktreotid

Oktreotid
IUPAC ime
	(4R,7S,10S,13R,16S,19R)-19-[(2R)-2-amino-3-fenilpropanamido]-10-(4-aminobutil)-16-benzil-N-[(2R,3R)-1,3-dihidroksibutan-2-il]-7-(1-hidroksietil)-13-(1H-indol-3-ilmetil)-6,9,12,15,18-pentaokso-1,2-ditia-5,8,11,14,17-pentaazacikloikosan-4-karboksamid
Klinički podaci
Prodajno ime	Atrigel, Longastatin, Sandostatin, Sandostatin LAR
Drugs.com	Monografija
Način primene	Intramaskularno; Intravenozno
Farmakokinetički podaci
Izlučivanje	Oko 32% se izlučuje nepromenjeno u urin.
Identifikatori
CAS broj	83150-76-9
ATC kod	H01CB02 (WHO)
DrugBank	DB00104
KEGG	C07306
Hemijski podaci
Formula	C49H66N10O10S2
Molarna masa	1019.239
	SMILES C[C@@H](O)[C@@H](CO)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](N)CC2=CC=CC=C2)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@H](CC2=CNC3=C2C=CC=C3)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)O)C(=O)N1; ;
	InChI InChI=1S/C49H66N10O10S2/c1-28(61)39(25-60)56-48(68)41-27-71-70-26-40(57-43(63)34(51)21-30-13-5-3-6-14-30)47(67)54-37(22-31-15-7-4-8-16-31)45(65)55-38(23-32-24-52-35-18-10-9-17-33(32)35)46(66)53-36(19-11-12-20-50)44(64)59-42(29(2)62)49(69)58-41/h3-10,13-18,24,28-29,34,36-42,52,60-62H,11-12,19-23,25-27,50-51H2,1-2H3,(H,53,66)(H,54,67)(H,55,65)(H,56,68)(H,57,63)(H,58,69)(H,59,64)/t28-,29?,34-,36+,37+,38-,39-,40+,41+,42+/m1/s1 ; Key:DEQANNDTNATYII-RRCPSWKPSA-N ;

Oktreotid je acetatna so cikličnog oktapeptida. On je dugotrajni oktapeptid ima farmakološka svojstva koja oponašaju prirodni hormon somatostatin.^[1]^[2]^[3]

Reference

^ Uhl W, Anghelacopoulos SE, Friess H, Buchler MW: The role of octreotide and somatostatin in acute and chronic pancreatitis. Digestion. 1999;60 Suppl 2:23-31. PMID 10207228
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMID 21059682.
^ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. 36 (Database issue): D901—6. PMID 18048412.

Spoljašnje veze

Octreotide

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Uhl W, Anghelacopoulos SE, Friess H, Buchler MW: The role of octreotide and somatostatin in acute and chronic pancreatitis. Digestion. 1999;60 Suppl 2:23-31. PMID 10207228

[2] Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMID 21059682.

[3] Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (Nucleic Acids Res) (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. 36 (Database issue): D901—6. PMID 18048412.

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