Orotat fosforiboziltransferaza
Orotat fosforiboziltransferaza (EC 2.4.2.10, orotidilna kiselina fosforilaza, orotidin-5'-fosfat pirofosforilaza, OPRTaze, orotat fosforibozil pirofosfat transferaza, orotinsko kiselinska fosforiboziltransferaza, orotidin 5'-monofosfatna pirofosforilaza, orotidin monofosfatna pirofosforilaza, orotidinska fosforiboziltransferaza, orotidilatna fosforiboziltransferaza, orotidilatna pirofosforilaza, orotidilno kiselinska pirofosforilaza, orotidilna fosforilaza, orotidilna pirofosforilaza) je enzim sa sistematskim imenom orotidin-5'-fosfat:difosfat fosfo-alfa-D-ribozil-transferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Orotat fosforiboziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 2.4.2.10 | ||||||||
| CAS broj | 9030-25-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Enzim iz viših eukariota takođe katalizuje reakcije enzima EC 4.1.1.23, orotidin-5'-fosfat dekarboksilaza.
Reference
уреди- ^ Jones, M.E., Kavipurapu, P.R. and Traut, T.W. (1978). „Orotate phosphoribosyltransferase: orotidylate decarboxylase (Ehrlich ascites cell)”. Methods Enzymol. 51: 155—167. PMID 692383.
- ^ Lieberman, I., Kornberg, A. and Simms, E.S. (1955). „Enzymatic synthesis of pyrimidine nucleotides. Orotidine-5′-phosphate and uridine-5′-phosphate”. J. Biol. Chem. 215: 403—415. PMID 14392174.
- ^ McClard, R.W., Black, M.J., Livingstone, L.R. and Jones, M.E. (1980). „Isolation and initial characterization of the single polypeptide that synthesizes uridine 5′-monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography of uridine-5′-monophosphate synthase”. Biochemistry. 19: 4699—4706. PMID 6893554.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Orotate+phosphoribosyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
