Holo-(acil-nosilac-protein) sintaza
(преусмерено са P-pant transferaza)
Holo-(acil-nosilac-protein) sintaza (EC 2.7.8.7, acil nosilac protein holoprotein (holo-ACP) sintetaza, holo-ACP sintetaza, koenzim A:masna kiselina sintetaza apoenzim 4'-fosfopantetein transferaza, holosintaza, acil nosilac protein sintetaza, PPTase, AcpS, ACPS, acil nosilac protein sintaza, P-pant transferaza, KoA:apo-(acil-nosilac-protein) panteteinfosfotransferaza, KoA-(4'-fosfopantetein):apo-(acil-nosilac-protein) 4'-panteteinfosfotransferaza) je enzim sa sistematskim imenom KoA-(4'-fosfopantetein):apo-(acil-nosilac protein) 4'-panteteinfosfotransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Holo-(acil-nosilac-protein) sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.8.7 | ||||||||
| CAS broj | 37278-30-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- KoA-[4'-fosfopantetein] + apo-[acil-nosilac protein] adenozin 3',5'-bisfosfat + holo-[acil-nosilac protein]
Za rad ovog enzima je neophodan jon Mg2+.
Reference
уреди- ^ Elovson, J. & Vagelos, P.R. (1968). „Acyl carrier protein. X. Acyl carrier protein synthetase”. J. Biol. Chem. 243: 3603—3611. PMID 4872726.
- ^ Prescott, D.J. & Vagelos, P.R. (1972). „Acyl carrier protein”. Adv. Enzymol. Relat. Areas Mol. Biol. 36: 269—311. PMID 4561013.
- ^ Lambalot, R.H., Gehring, A.M., Flugel, R.S., Zuber, P., LaCelle, M., Marahiel, M.A., Reid, R., Khosla, C. and Walsh, C.T. (1996). „A new enzyme superfamily - the phosphopantetheinyl transferases”. Chem. Biol. 3: 923—936. PMID 8939709.
- ^ Walsh, C.T., Gehring, A.M., Weinreb, P.H., Quadri, L.E.N. and Flugel, R.S. (1997). „Post-translational modification of polyketide and nonribosomal peptide synthases”. Curr. Opin. Chem. Biol. 1: 309—315. PMID 9667867.
- ^ Mootz, H.D., Finking, R. and Marahiel, M.A. (2001). „4′-Phosphopantetheine transfer in primary and secondary metabolism of Bacillus subtilis”. J. Biol. Chem. 276: 37289—37298. PMID 11489886.
- ^ Joshi, A.K., Zhang, L., Rangan, V.S. and Smith, S. (2003). „Cloning, expression, and characterization of a human 4′-phosphopantetheinyl transferase with broad substrate specificity”. J. Biol. Chem. 278: 33142—33149. PMID 12815048.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Holo-(acyl-carrier-protein)+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
