Penicilopepsin
Penicilopepsin (EC 3.4.23.20, peptidaza A, Penicillium janthinellum aspartinska proteinaza, kiselinska proteaza A, Penicillium citrinum kiselinska proteinaza, Penicillium ciklopium kiselinska proteinaza, Penicillium expansum kiselinska proteinaza, Penicillium janthinellum kiselinska proteinaza, Penicillium expansum aspartinska proteinaza, Penicillium aspartinska proteinaza, Penicillium caseicolum aspartinska proteinaza, Penicillium roqueforti kiselinska proteinaza, Penicillium duponti aspartinska proteinaza, Penicillium citrinum aspartinska proteinaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Penicilopepsin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.23.20 | ||||||||
| CAS broj | 2620465 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Hidroliza proteina sa širokom specifičnošću, sličnom pepsinu A. Postoji preferencija za hidrofobne ostatke u P1 i P1', ali takođe dolazi do razlaganja Gly20-Glu u B lancu insulina.
Ovaj enzim je prisutan u gljivi Penicillium janthinellum.
Reference уреди
- ^ Mains, G., Takahashi, M., Sodek, J. and Hofmann, T. (1971). „The specificity of penicillopepsin”. Can. J. Biochem. 49: 1134—1149. PMID 4946839.
- ^ Zevaco, C., Hermier, J. and Gripon, J.-C. (1973). „Le système protéolytique de Penicillium roqueforti. II - Purification et propriétés de la protéase acide”. Biochimie. 55: 1353—1360. PMID 4790849.
- ^ Emi, S., Myers, D.V. and Iacobucci, G.A. (1976). „Purification and properties of the thermostable acid protease of Penicillium duponti”. Biochemistry. 15: 842—848. PMID 2287.
- ^ Hofmann, T. (1976). „Penicillopepsin”. Methods Enzymol. 45: 434—450. PMID 1012008.
- ^ Hsu, I.-N., Delbaere, L.T.J., James, M.N.G. and Hofmann, T. (1977). „Penicillopepsin from Penicillium janthinellum crystal structure at 2.8 Å and sequence homology with porcine pepsin”. Nature. 266: 140—144. PMID 323722.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Penicillopepsin на US National Library of Medicine Medical Subject Headings (MeSH)
