Pentalenenska sintaza
Pentalenenska sintaza (EC 4.2.3.7, pentalenenska sintetaza) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat difosfat-lijaza (ciklizacija, formira pentalenen).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Pentalenenska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.3.7 | ||||||||
| CAS broj | 90597-46-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (2E,6E)-farnezil difosfat pentalenen + difosfat
Ovaj enzim je prisutan u Streptomyces avermitilis.
Reference
уреди- ^ Cane, D.E. (1983). „Cell-free studies of monoterpene and sesquiterpene biosynthesis”. Biochem. Soc. Trans. 11: 510—515. PMID 6642060.
- ^ Cane, D.E. & Tillman, A.M. (1983). „Pentalenene biosynthesis and the enzymic cyclization of farnesyl pyrophosphate”. J. Am. Chem. Soc. 105: 122—124.
- ^ Cane, D.E., Sohng, J.K., Lamberson, C.R., Rudnicki, S.M., Wu, Z., Lloyd, M.D., Oliver, J.S. and Hubbard, B.R. (1994). „Pentalenene synthase. Purification, molecular cloning, sequencing, and high-level expression in Escherichia coli of a terpenoid cyclase from Streptomyces UC5319”. Biochemistry. 33: 5846—5857. PMID 8180213.
- ^ Cane, D.E., Abell, C., Harrison, P.H., Hubbard, B.R., Kane, C.T., Lattman, R., Oliver, J.S. and Weiner, S.W. (1991). „Terpenoid biosynthesis and the stereochemistry of enzyme-catalysed allylic addition-elimination reactions”. Philos. Trans. R. Soc. Lond. B Biol. Sci. 332: 123—129. PMID 1678531.
- ^ Lesburg, C.A., Zhai, G., Cane, D.E. and Christianson, D.W. (1997). „Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology”. Science. 277: 1820—1824. PMID 9295272.
- ^ Zu, L., Xu, M., Lodewyk, M.W., Cane, D.E., Peters, R.J. and Tantillo, D.J. (2012). „Effect of isotopically sensitive branching on product distribution for pentalenene synthase: support for a mechanism predicted by quantum chemistry”. J. Am. Chem. Soc. 134: 11369—11371. PMID 22738258.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Pentalenene+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
