Polo kinaza
Polo kinaza (EC 2.7.11.21, Cdc5, Cdc5p, Plk, PLK, Plk1, Plo1, polo serin-treonin kinaza, polo-like kinaza, polo-like kinaza 1, serin/treonin-specifična Drosophila kinaza polo, STK21) je enzim sa sistematskim imenom ATP:proteinska fosfotransferaza (spindle-pole-zavisna).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Polo kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.11.21 | ||||||||
| CAS broj | 149433-93-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- ATP + protein ADP + fosfoprotein
Ovaj enzim vezuje pol vretena tokom mitoze i ima važnu ulogu tokom hromozomne segregacije.
Reference уреди
- ^ Llamazares, S., Moreira, A., Tavares, A., Girdham, C., Spruce, B.A., Gonzalez, C., Karess, R.E., Glover, D.M. and Sunkel, C.E. (1991). „polo encodes a protein kinase homolog required for mitosis in Drosophila”. Gene. 5: 2153—2165. PMID 1660828.
- ^ Golsteyn, R.M., Mundt, K.E., Fry, A.M. and Nigg, E.A. (1995). „Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function”. J. Cell Biol. 129: 1617—1628. PMID 7790358.
- ^ Mulvihill, D.P. & Hyams, J.S. (2002). „Cytokinetic actomyosin ring formation and septation in fission yeast are dependent on the full recruitment of the polo-like kinase Plo1 to the spindle pole body and a functional spindle assembly checkpoint. J”. Cell. 115: 3575—3586. PMID 12186944.
- ^ Ohkura, H. (2003). „Phosphorylation: polo kinase joins an elite club”. Curr. Biol. 13: R912—R914. PMID 14654016.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Polo+kinase на US National Library of Medicine Medical Subject Headings (MeSH)
