Википедија

Proliferatini ćelijski nuklearni antigen

(преусмерено са Proliferativni ćelijski nuklearni antigen)

Proliferativni ćelijski nuklearni antigen (PCNA) je DNK stega koja deluje kao faktor procesivnosti za DNK polimerazu δ u eukariotskim ćelijama i koja je esencijalna za replikaciju. PCNA je homotrimer koji ostvaruje svoju procesivnost putem obuhvatanja DNK, pri čemu ona deluje kao osnova na kojoj se vezuju drugi proteini koji su neophodni za DNK replikaciju, DNK popravku, remodelovanje hromatina i epigenetiku.[1]

Proliferating cell nuclear antigen
Identifikatori
Alijasi
Spoljašnji IDGeneCards: [1]
Obrazac RNK izražavanja
More reference expression data
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Mnogi proteini formiraju interakcije sa dva poznata PCNA-interagujuća motiva: PCNA interagujuća peptidna (PIP) kutija[2] i AlkB homolog 2 PCNA interagujući motiv (APIM).[3] Proteinsko vezivanje za PCNA putem PIP-kutije se uglavnom ostvaruje tokom DNK replikacije, dok su proteini koji se vezuju za PCNA putem APIM prvenstveno važni u kontekstu genotoksičnog stresa.[4]

U responsu na DNK oštećenje, ovaj protein biva ubikvitinisan i učestvuje u putu RAD6 zavisne DNK popravke. Poznate su dve transkriptne varijante koje kodiraju isti protein. Pseudogeni ovog gena su prisutni na hromozomu 4 i na X hromozomu.[5]

Interakcije

уреди

PCNA formira interakcije sa:

Proteini koji formiraju interakcije sa PCNA preko APIM obuhvataju ljudski AlkB homolog 2, TFIIS-L, TFII-I, Rad51B,[3] XPA,[69] ZRANB3,[70] i FBH1.[71]

Reference

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