Proteazomski endopeptidazni kompleks
Proteazomski endopeptidazni kompleks (EC 3.4.25.1, ingensin, makropain, multicatalytic endopeptidazni kompleks, prosom, multikatalitička proteinaza (kompleks), MCP, velika multikatalitička proteaza, multikatalitička proteinaza, proteazomska organela, alkalna proteaza, 26S proteaza, trikorn proteinaza, trikorn proteaza) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Proteazomski endopeptidazni kompleks | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Proteasome core particle, di-heptamer, Archaea | |||||||||
| Identifikatori | |||||||||
| EC broj | 3.4.25.1 | ||||||||
| CAS broj | 140879-24-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Razlaganje peptidnih veza sa veoma širokom specifičnošću
Ovaj enzim pripada peptidaznoj familiji T1.
Reference
уреди- ^ Seemüller, E., Lupas, A., Stock, D., Löwe, J., Huber, R. and Baumeister, W. (1995). „Proteasome from Thermoplasma acidophilum: a threonine protease”. Science. 268: 579—582. PMID 7725107.
- ^ Coux, O., Tanaka, K. and Goldberg, A.L. (1996). „Structure and functions of the 20S and 26S proteasomes”. Annu. Rev. Biochem. 65: 801—847. PMID 8811196.
- ^ Groll, M., Ditzel, L., Löwe, J., Stock, D., Bochtler, M., Bartunik, H.D. and Huber, R. (1997). „Structure of 20S proteasome from yeast at 2.4Å resolution”. Nature. 386: 463—471. PMID 9087403.
- ^ Dick, T.P., Nussbaum, A.K., Deeg, M., Heinemeyer, W., Groll, M., Schirle, M., Keilholz, W., Stevanovic, S., Wolf, D.H., Huber, R., Rammensee, H.G. and Schild, H. (1998). „Contribution of proteasomal β-subunits to the cleavage of peptide substrates analyzed with yeast mutants”. J. Biol. Chem. 273: 25637—25646. PMID 9748229.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Proteasome+endopeptidase+complex на US National Library of Medicine Medical Subject Headings (MeSH)
