Rosiglitazon je organsko jedinjenje, koje sadrži 18 atoma ugljenika i ima molekulsku masu od 357,427 Da.[1][2][3][4]

Rosiglitazon
Rosiglitazone.svg
Rosiglitazone ball-and-stick.png
Klinički podaci
Prodajno imeAvandia, Rosiglizole
Drugs.comMonografija
Način primeneOralno
Farmakokinetički podaci
Poluvreme eliminacije3-4 h
Identifikatori
CAS broj122320-73-4 ДаY
ATC kodA10BG02 (WHO)
PubChemCID 77999
IUPHAR/BPS1056
DrugBankDB00412 ДаY
ChemSpider70383 ДаY
ChEBICHEBI:50122 ДаY
ChEMBLCHEMBL121 ДаY
Hemijski podaci
FormulaC18H19N3O3S
Molarna masa357,427
Fizički podaci
Tačka topljenja122—123 °C (252—253 °F)

OsobineУреди

Osobina Vrednost
Broj akceptora vodonika 6
Broj donora vodonika 1
Broj rotacionih veza 7
Particioni koeficijent[5] (ALogP) 3,3
Rastvorljivost[6] (logS, log(mol/L)) -4,0
Polarna površina[7] (PSA, Å2) 96,8

ReferenceУреди

  1. ^ Mohanty P, Aljada A, Ghanim H, Hofmeyer D, Tripathy D, Syed T, Al-Haddad W, Dhindsa S, Dandona P: Evidence for a potent antiinflammatory effect of rosiglitazone. J Clin Endocrinol Metab. 2004 Jun;89(6):2728-35. PMID 15181049
  2. ^ Kahn SE, Haffner SM, Heise MA, Herman WH, Holman RR, Jones NP, Kravitz BG, Lachin JM, O'Neill MC, Zinman B, Viberti G: Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med. 2006 Dec 7;355(23):2427-43. Epub 2006 Dec 4. PMID 17145742
  3. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.  уреди
  4. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.  уреди
  5. ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 
  6. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.  уреди
  7. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.  уреди

LiteraturaУреди

Spoljašnje vezeУреди

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