23S rRNK (uridin2552-2'-O)-metiltransferaza
(преусмерено са S-adenozil-L-metionin:23S rRNK (uridin2552-2'-O-)-metiltransferaza)
23S rRNK (uridin2552-2'-O)-metiltransferaza (EC 2.1.1.166, Um(2552) 23S ribosomal RNK metiltransferaza, protein toplotnog šoka RrmJ, RrmJ, FTSJ, Um2552 metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:23S rRNK (uridin2552-2'-O-)-metiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 23S rRNK (uridin2552-2'-O)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.166 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + uridin2552 in 23S rRNK S-adenozil-L-homocistein + 2'-O-metiluridin2552 in 23S rRNK
Ovaj enzim katalizuje 2'-O-metilaciju univerzalno konzerviranog U2552 u A petlji 23S rRNK.
Reference уреди
- ^ Caldas, T., Binet, E., Bouloc, P., Costa, A., Desgres, J. and Richarme, G. (2000). „The FtsJ/RrmJ heat shock protein of Escherichia coli is a 23 S ribosomal RNA methyltransferase”. J. Biol. Chem. 275: 16414—16419. PMID 10748051.
- ^ Hager, J., Staker, B.L., Bugl, H. and Jakob, U. (2002). „Active site in RrmJ, a heat shock-induced methyltransferase”. J. Biol. Chem. 277: 41978—41986. PMID 12181314.
- ^ Hager, J., Staker, B.L. and Jakob, U. (2004). „Substrate binding analysis of the 23S rRNA methyltransferase RrmJ”. J. Bacteriol. 186: 6634—6642. PMID 15375145.
- ^ Bugl, H., Fauman, E.B., Staker, B.L., Zheng, F., Kushner, S.R., Saper, M.A., Bardwell, J.C. and Jakob, U. (2000). „RNA methylation under heat shock control”. Mol. Cell. 6: 349—360. PMID 10983982.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- 23S+rRNA+(uridine2552-2'-O)-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
