Teobromin sintaza
(преусмерено са S-adenozil-L-metionin:7-metilksantin 3-N-metiltransferaza)
Teobromin sintaza (EC 2.1.1.159, monometilksantinska metiltransferaza, MXMT, CTS1, CTS2, S-adenozil-L-metionin:7-metilksantin 3-N-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:7-metilksantin N3-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Teobromin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.159 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozil-L-metionin + 7-metilksantin S-adenozil-L-homocistein + 3,7-dimetilksantin
Ovo je treći enzim u biosintezi kofeina. Enzim takođe može da katalizuje konverziju paraksantina u kofein.
Reference уреди
- ^ Ogawa, M., Herai, Y., Koizumi, N., Kusano, T. and Sano, H. (2001). „7-Methylxanthine methyltransferase of coffee plants. Gene isolation and enzymatic properties”. J. Biol. Chem. 276: 8213—8218. PMID 11108716.
- ^ Uefuji, H., Ogita, S., Yamaguchi, Y., Koizumi, N. and Sano, H. (2003). „Molecular cloning and functional characterization of three distinct N-methyltransferases involved in the caffeine biosynthetic pathway in coffee plants”. Plant Physiol. 132: 372—380. PMID 12746542.
- ^ Yoneyama, N., Morimoto, H., Ye, C.X., Ashihara, H., Mizuno, K. and Kato, M. (2006). „Substrate specificity of N-methyltransferase involved in purine alkaloids synthesis is dependent upon one amino acid residue of the enzyme”. Mol. Genet. Genomics. 275: 125—135. PMID 16333668.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Theobromine+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
