Demetilrebekamicin-D-glukoza O-metiltransferaza
Demetilrebekamicin-D-glukoza O-metiltransferaza (EC 2.1.1.164, RebM) je enzim sa sistematskim imenom S-adenozil-L-metionin:demetilrebekamicin-D-glukoza O-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Demetilrebekamicin-D-glukoza O-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.164 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- 4'-demetilrebekmicin + S-adenozil-L-metionin rebekamicin + S-adenozil-L-homocistein
Ovaj enzim katalizuje zadnji korak biosinteze rebekamicina, indolokarbazolnog alkaloida koji formira actinobakterija Lechevalieria aerocolonigenes.
Reference уреди
- ^ Zhang, C., Albermann, C., Fu, X., Peters, N.R., Chisholm, J.D., Zhang, G., Gilbert, E.J., Wang, P.G., Van Vranken, D.L. and Thorson, J.S. (2006). „RebG- and RebM-catalyzed indolocarbazole diversification”. Chembiochem. 7: 795—804. PMID 16575939.
- ^ Singh, S., McCoy, J.G., Zhang, C., Bingman, C.A., Phillips, G.N., Jr. and Thorson, J.S. (2008). „Structure and mechanism of the rebeccamycin sugar 4′-O-methyltransferase RebM”. J. Biol. Chem. 283: 22628—22636. PMID 18502766.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Demethylrebeccamycin-D-glucose+O-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
