Salutaridin sintaza
Salutaridin sintaza (EC 1.14.21.4, (R)-retikulinska oksidaza (C-C fenolno spajanje)) je enzim sa sistematskim imenom (R)-retikulin,NADPH:kiseonik oksidoreduktaza (C-C fenolno spajanje).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Salutaridin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.21.4 | ||||||||
| CAS broj | 149433-84-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- (R)-retikulin + NADPH + H+ + O2 salutaridin + NADP+ + 2H2O
Ovaj enzim je hem-tiolatni protein (P-450). On formira morfinanski alkaloid salutaridin putem intramolekularne fenolne oksidacije retikulina bez inkorporacije kiseonika u produkt.
Reference уреди
- ^ Gerady, R. & Zenk, M.H. (1993). „Formation of salutaridine from (R)-reticuline by a membrane-bound cytochrome P-450 enzyme from Papaver somniferum”. Phytochemistry. 32: 79—86.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Salutaridine+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
