Sfingomijelin sintaza
Sfingomijelin sintaza (EC 2.7.8.27, SM sintaza, SMS1, SMS2) je enzim sa sistematskim imenom keramid:fosfatidilholin holinfosfotransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Sfingomijelin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.8.27 | ||||||||
| CAS broj | 58703-97-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- keramid + fosfatidilholin sfingomijelin + 1,2-diacil-sn-glicerol
Ova reakcija može da teče u oba smera.
Reference
уреди- ^ Ullman, M.D. & Radin, N.S. (1974). „The enzymatic formation of sphingomyelin from ceramide and lecithin in mouse liver”. J. Biol. Chem. 249: 1506—1512. PMID 4817756.
- ^ Voelker, D.R. & Kennedy, E.P. (1982). „Cellular and enzymic synthesis of sphingomyelin”. Biochemistry. 21: 2753—2759. PMID 7093220.
- ^ Huitema, K., van den Dikkenberg, J., Brouwers, J.F. and Holthuis, J.C. (2004). „Identification of a family of animal sphingomyelin synthases”. EMBO J. 23: 33—44. PMID 14685263.
- ^ Tafesse, F.G., Ternes, P. and Holthuis, J.C. (2006). „The multigenic sphingomyelin synthase family”. J. Biol. Chem. 281: 29421—29425. PMID 16905542.
- ^ Yamaoka, S., Miyaji, M., Kitano, T., Umehara, H. and Okazaki, T. (2004). „Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells”. J. Biol. Chem. 279: 18688—18693. PMID 14976195.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Sphingomyelin+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
