Spermidin sintaza
Spermidin sintaza (EC 2.5.1.16, aminopropiltransferaza, putrescinska aminopropiltransferaza, spermidinska sintetaza, SpeE) je enzim sa sistematskim imenom S-adenozilmetioninamin:putrescin 3-aminopropiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Spermidin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Spermidin sintaza tetramer, Bacillus subtilis | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.5.1.16 | ||||||||
| CAS broj | 37277-82-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- S-adenozilmetioninamin + putrescin 5'-S-metil-5'-tioadenozin + spermidin
Ovaj enzim nije identičan sa EC 2.5.1.22, sperminskom sintazom. Enzim sisara je visoko specifičan, dok bakterijski enzim može da koristi druge akceptore i može da sintetizuje spermin.
Reference
уреди- ^ Hannonen, P., Janne, J. and Raina, A. (1972). „Partial purification and characterization of spermine synthase from rat brain”. Biochim. Biophys. Acta. 289: 225—231. PMID 4564056.
- ^ Pegg, A.E., Shuttleworth, K. and Hibasami, H. (1981). „Specificity of mammalian spermidine synthase and spermine synthase”. Biochem. J. 197: 315—320. PMID 6798961.
- ^ Tabor, C.W. (1962). „Propylamine transferase (spermidine synthesis)”. Methods Enzymol. 5: 761—765.
- ^ Tabor, H. & Tabor, C.W. (1972). „Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine, and related amines”. Adv. Enzymol. Relat. Areas Mol. Biol. 36: 203—268. PMID 4628436.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Spermidine+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
