Srebro sulfadiazin
Srebro sulfadiazin je organsko jedinjenje, koje sadrži 10 atoma ugljenika i ima molekulsku masu od 357,137 Da.[1][2][3][4][5]
 | |
| Klinički podaci | |
|---|---|
| Prodajno ime | Dermazin, Flamazine, Sildaflo, Silvadene |
| Drugs.com | sulfadiazine.html Monografija |
| Način primene | topikalno |
| Identifikatori | |
| CAS broj | 22199-08-2  |
| ATC kod | D06BA01 (WHO) |
| PubChem | CID 441244 |
| DrugBank | DB05245 |
| ChemSpider | 390017 |
| ChEBI | CHEBI:9142 |
| ChEMBL | CHEMBL1200766 |
| Hemijski podaci | |
| Formula | C10H9AgN4O2S |
| Molarna masa | 357,137 |
| |
| |
| Fizički podaci | |
| Tačka topljenja | 285 °C (545 °F) |
OsobineУреди
| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 5 |
| Broj donora vodonika | 1 |
| Broj rotacionih veza | 3 |
| Particioni koeficijent[6] (ALogP) | 0,4 |
| Rastvorljivost[7] (logS, log(mol/L)) | -1,4 |
| Polarna površina[8] (PSA, Å2) | 145,6 |
ReferenceУреди
- ^ Fox CL Jr, Modak SM: Mechanism of silver sulfadiazine action on burn wound infections. Antimicrob Agents Chemother. 1974 Jun;5(6):582-8. PMID 15825409
- ^ Russell AD, Hugo WB: Antimicrobial activity and action of silver. Prog Med Chem. 1994;31:351-70. PMID 8029478
- ^ Percival SL, Bowler PG, Russell D: Bacterial resistance to silver in wound care. J Hosp Infect. 2005 May;60(1):1-7. PMID 15823649
- ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126.
- ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
- ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
- ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
- ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
LiteraturaУреди
- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje vezeУреди
 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |