Sulfacetamid je organsko jedinjenje, koje sadrži 8 atoma ugljenika i ima molekulsku masu od 214,242 Da.[1][2][3][4][5]

Sulfacetamid
Klinički podaci
Prodajno imeAlbamine, Albucid, Alesten, Bleph-10
Drugs.comMonografija
Način primeneOftalmički
Farmakokinetički podaci
Poluvreme eliminacije7-12,8 h
Identifikatori
CAS broj144-80-9 ДаY
ATC kodS01AB04 (WHO)
PubChemCID 5320
DrugBankDB00634 ДаY
ChemSpider5129 ДаY
ChEBICHEBI:63845 ДаY
ChEMBLCHEMBL455 ДаY
Hemijski podaci
FormulaC8H10N2O3S
Molarna masa214,242
  • CC(=O)NS(=O)(=O)C1=CC=C(N)C=C1
  • InChI=1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11) ДаY
  • Key:SKIVFJLNDNKQPD-UHFFFAOYSA-N ДаY
Fizički podaci
Tačka topljenja183 °C (361 °F)
Osobina Vrednost
Broj akceptora vodonika 4
Broj donora vodonika 2
Broj rotacionih veza 2
Particioni koeficijent[6] (ALogP) -0,2
Rastvorljivost[7] (logS, log(mol/L)) -2,0
Polarna površina[8] (PSA, Å2) 97,6

Reference

уреди
  1. ^ Hull CA, Johnson SM: A double-blind comparative study of sodium sulfacetamide lotion 10% versus selenium sulfide lotion 2.5% in the treatment of pityriasis (tinea) versicolor. Cutis. 2004 Jun;73(6):425-9. PMID 15224788
  2. ^ Del Rosso JQ: Evaluating the role of topical therapies in the management of rosacea: focus on combination sodium sulfacetamide and sulfur formulations. Cutis. 2004 Jan;73(1 Suppl):29-33. PMID 14959943
  3. ^ Roth HW, Leimbeck R, Sonnenschein B, Anger CB, Weber S: [The effective antibacterial spectrum of sulfacetamide] Klin Monatsbl Augenheilkd. 1992 Mar;200(3):182-6. PMID 1578876
  4. ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126. 
  5. ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958. 
  6. ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. 
  7. ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. 
  8. ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. 

Literatura

уреди

Spoljašnje veze

уреди


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