Tau-protein kinaza
Tau-protein kinaza (EC 2.7.11.26, ATP:tau-protein O-hosfotransferaza, moždana proteinska kinaza PK40erk, cdk5/p20, CDK5/p23, glikogenska sintaza kinaza-3beta, GSK, protein tau kinaza, STK31, tau kinaza, tau-protein kinaza I, tau-protein kinaza II, tau-tubulin kinaza, TPK, TPK I, TPK II, TTK) je enzim sa sistematskim imenom ATP:(tau-protein) O-fosfotransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Tau-protein kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.7.11.26 | ||||||||
| CAS broj | 111694-09-8 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ovaj enzim se aktivira tubulinom.
Reference
уреди- ^ Ishiguro, K., Ihara, Y., Uchida, T. and Imahori, K. (1988). „A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau”. J. Biochem. (Tokyo). 104: 319—321. PMID 2467901.
- ^ Lund, E.T., McKenna, R., Evans, D.B., Sharma, S.K. and Mathews, W.R. (2001). „Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry”. J. Neurochem. 76: 1221—1232. PMID 11181841.
- ^ Michel, G., Mercken, M., Murayama, M., Noguchi, K., Ishiguro, K., Imahori, K. and Takashima, A. (1998). „Characterization of tau phosphorylation in glycogen synthase kinase-3β and cyclin dependent kinase-5 activator (p23) transfected cells”. Biochim. Biophys. Acta. 1380: 177—182. PMID 9565682.
- ^ Aoki, M., Iwamoto-Sugai, M., Sugiura, I., Sasaki, C., Hasegawa, T., Okumura, C., Sugio, S., Kohno, T. and Matsuzaki, T. (2000). „Expression, purification and crystallization of human tau-protein kinase I/glycogen synthase kinase-3beta”. Acta Crystallogr. D Biol. Crystallogr. 56: 1464—1465. PMID 11053853.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Tau-protein+kinase на US National Library of Medicine Medical Subject Headings (MeSH)
