Timidilat sintaza (FAD)
Timidilat sintaza (FAD) (EC 2.1.1.148, Thy1, ThyX) je enzim sa sistematskim imenom 5,10-metilintetrahidrofolat,FADH2:dUMP C-metiltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Timidilat sintaza (FAD) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Timidilat sintaza (FAD) tetramer, Thermotoga maritima | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.1.1.148 | ||||||||
| CAS broj | 850167-13-4 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 5,10-metilintetrahidrofolat + dUMP + NADPH + H+ dTMP + tetrahidrofolat + NADP+
Ovaj enzim sadrži FAD.
Reference
уреди- ^ Myllykallio, H., Lipowski, G., Leduc, D., Filee, J., Forterre, P. and Liebl, U. (2002). „An alternative flavin-dependent mechanism for thymidylate synthesis”. Science. 297: 105—107. PMID 12029065.
- ^ Griffin, J., Roshick, C., Iliffe-Lee, E. and McClarty, G. (2005). „Catalytic mechanism of Chlamydia trachomatis flavin-dependent thymidylate synthase”. J. Biol. Chem. 280: 5456—5467. PMID 15591067.
- ^ Graziani, S., Bernauer, J., Skouloubris, S., Graille, M., Zhou, C.Z., Marchand, C., Decottignies, P., van Tilbeurgh, H., Myllykallio, H. and Liebl, U. (2006). „Catalytic mechanism and structure of viral flavin-dependent thymidylate synthase ThyX”. J. Biol. Chem. 281: 24048—24057. PMID 16707489.
- ^ Koehn, E.M., Fleischmann, T., Conrad, J.A., Palfey, B.A., Lesley, S.A., Mathews, I.I. and Kohen, A. (2009). „An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene”. Nature. 458: 919—923. PMID 19370033.
- ^ Koehn, E.M. & Kohen, A. (2010). „Flavin-dependent thymidylate synthase: a novel pathway towards thymine”. Arch. Biochem. Biophys. 493: 96—102. PMID 19643076.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Thymidylate+synthase+(FAD) на US National Library of Medicine Medical Subject Headings (MeSH)
