Timidilat sintaza (FAD) (EC 2.1.1.148, Thy1, ThyX) je enzim sa sistematskim imenom 5,10-metilintetrahidrofolat,FADH2:dUMP C-metiltransferaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Timidilat sintaza (FAD)
Timidilat sintaza (FAD) tetramer, Thermotoga maritima
Identifikatori
EC broj2.1.1.148
CAS broj850167-13-4
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum
5,10-metilintetrahidrofolat + dUMP + NADPH + H+ dTMP + tetrahidrofolat + NADP+

Ovaj enzim sadrži FAD.

Reference

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  1. ^ Myllykallio, H., Lipowski, G., Leduc, D., Filee, J., Forterre, P. and Liebl, U. (2002). „An alternative flavin-dependent mechanism for thymidylate synthesis”. Science. 297: 105—107. PMID 12029065. 
  2. ^ Griffin, J., Roshick, C., Iliffe-Lee, E. and McClarty, G. (2005). „Catalytic mechanism of Chlamydia trachomatis flavin-dependent thymidylate synthase”. J. Biol. Chem. 280: 5456—5467. PMID 15591067. 
  3. ^ Graziani, S., Bernauer, J., Skouloubris, S., Graille, M., Zhou, C.Z., Marchand, C., Decottignies, P., van Tilbeurgh, H., Myllykallio, H. and Liebl, U. (2006). „Catalytic mechanism and structure of viral flavin-dependent thymidylate synthase ThyX”. J. Biol. Chem. 281: 24048—24057. PMID 16707489. 
  4. ^ Koehn, E.M., Fleischmann, T., Conrad, J.A., Palfey, B.A., Lesley, S.A., Mathews, I.I. and Kohen, A. (2009). „An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX gene”. Nature. 458: 919—923. PMID 19370033. 
  5. ^ Koehn, E.M. & Kohen, A. (2010). „Flavin-dependent thymidylate synthase: a novel pathway towards thymine”. Arch. Biochem. Biophys. 493: 96—102. PMID 19643076. 

Literatura

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Spoljašnje veze

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