Trombin
Trombin (EC 3.4.21.5, trombaza, trombofort, topikal, trombin-C, tropostazin, aktivatirani krvno-koagulacioni faktor II, krvno-koagulacioni faktor IIa, faktor IIa, E trombin, beta-trombin, gama-trombin) je enzim.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Trombin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifikatori | |||||||||
| EC broj | 3.4.21.5 | ||||||||
| CAS broj | 2594047 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- Selektivno razlaganje Arg-Gly veza u fibrinogenu čime se formira fibrin i odvajaju fibrinopeptidi A i B
Ovaj enzim se formira iz protrombina.
Reference уреди
- ^ Baughman, D.J. (1970). „Thrombin assay”. Methods Enzymol. 19: 145—157.
- ^ Magnusson, S. (1970). „Bovine prothrombin and thrombin”. Methods Enzymol. 19: 157—184.
- ^ Miller, K.D. (1970). „Horse prothrombin”. Methods Enzymol. 19: 140—145.
- ^ Lundblad, R.L., Kingdon, H.S. and Mann, K.G. (1976). „Thrombin”. Methods Enzymol. 45: 156—176. PMID 1011989.
- ^ Mann, K.G. (1976). „Prothrombin”. Methods Enzymol. 45: 123—156. PMID 1011988.
- ^ Davie, E.W., Fujikawa, K., Kurachi, K. and Kisiel, W. (1979). „The role of serine proteases in the blood coagulation cascade”. Adv. Enzymol. 48: 277—318. PMID 367103.
- ^ Cho, K., Tanaka, T., Cook, R.R., Kisiel, W., Fujikawa, K., Kurachi, K. and Powers, J.C. (1984). „Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates”. Biochemistry. 23: 644—650. PMID 6370301.
- ^ MacGillivray, R.T.A. & Davie, E.W. (1984). „Characterization of bovine prothrombin mRNA and its translation product”. Biochemistry. 23: 1626—1634. PMID 6326805.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
