Tropin dehidrogenaza
Tropin dehidrogenaza (EC 1.1.1.206, tropinon reduktaza (ambiguous), TR-I) je enzim sa sistematskim imenom tropin:NADP+ 3alfa-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Tropin dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.206 | ||||||||
| CAS broj | 118390-87-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- tropin + NADP+ tropinon + NADPH + H+
Tropinska dehidrogenaza takođe oksiduje druge tropan-3alfa-ole, ali ne i na korespondirajuće beta-derivate. Ovaj enzim zajedno sa EC 1.1.1.236, tropinonskom reduktazom II, predstavlja tačku grananja u tropanskom alkaloidnom metabolizmu. Tropin (produkt enzima EC 1.1.1.206 se inkorporira u hiosciamin i skopolamin, dok je pseudotropin (product enzima EC 1.1.1.236) prvi specifični metabolit na putu do kalistegina. Oba enzima su uvek zajedno prisutna u vrstama koji proizvode tropanski alkaloid. Oni imaju zajednički supstrat, tropinon, i striktno su stereospecifična.
Reference
уреди- ^ Koelen, K.J. & Gross, G.G. (1982). „Partial purification and properties of tropine dehydrogenase from root cultures of Datura stramonium”. Planta Med. 44: 227—230.
- ^ Couladis, M.M, Friesen, J.B., Landgrebe, M.E. and Leete, E. (1991). „Enzymes catalysing the reduction of tropinone to tropine and ψ-tropine isolated from the roots of Datura innoxia”. Pytochemistry. 30: 801—805.
- ^ Nakajima, K., Hashimoto, T. and Yamada, Y. (1993). „Two tropinone reductases with different stereospecificities are short-chain dehydrogenases evolved from a common ancestor”. Proc. Natl. Acad. Sci. USA. 90: 9591—9595. PMID 8415746.
- ^ äger, B. (2006). „Tropinone reductases, enzymes at the branch point of tropane alkaloid metabolism”. Phytochemistry. 67: 327—337. PMID 16426652.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- Tropinone+reductase+I на US National Library of Medicine Medical Subject Headings (MeSH)
