UMP kinaza
UMP kinaza (EC 2.7.4.22, uridilatba kinaza, UMPK, uridin monofosfatna kinaza, PyrH, UMP-kinaza, SmbA) je enzim sa sistematskim imenom ATP:UMP fosfotransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| UMP kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.4.22 | ||||||||
| CAS broj | 9036-23-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Ovaj enzim je striktno specifičan za UMP kao supstrat.
Reference уреди
- ^ Serina, L., Blondin, C., Krin, E., Sismeiro, O., Danchin, A., Sakamoto, H., Gilles, A.M. and Bârzu, O. (1995). „Escherichia coli UMP-kinase, a member of the aspartokinase family, is a hexamer regulated by guanine nucleotides and UTP”. Biochemistry. 34: 5066—5074. PMID 7711027.
- ^ Marco-Marín, C., Gil-Ortiz, F. and Rubio, V. (2005). „The crystal structure of Pyrococcus furiosus UMP kinase provides insight into catalysis and regulation in microbial pyrimidine nucleotide biosynthesis”. J. Mol. Biol. 352: 438—454. PMID 16095620.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- UMP+kinase на US National Library of Medicine Medical Subject Headings (MeSH)
