Ubihinon

Ubihinon
Nazivi
	IUPAC naziv 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-dekametiltetrakonta-2,6,10,14,18,22,26,30,34,38-dekaenil]-5, 6-dimetoksi-3-metilcikloheksa-2,5-dien-1,4-dion
Identifikacija
CAS broj	303-98-0 ;
3D model (Jmol)	interaktivna slika;
ChEBI	CHEBI:46245 ;
ChemSpider	4445197 ;
ECHA InfoCard	100.005.590
PubChem C ID	5281915;
UNII	EJ27X76M46 ;
	SMILES O=C1/C(=C(\C(=O)C(\OC)=C1\OC)C)C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)C; ; ; ; ; ;
Svojstva
Hemijska formula	C59H90O4
Molarna masa	863,37 g·mol−1
Srodna jedinjenja
Srodna jedinjenja	1,4-Benzohinon; Hinon; Plastohinon
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

Ubihinon (koenzim Q₁₀, ubikvinon, ubidekarenon, koenzim Q, CoQ₁₀, CoQ, Q₁₀) je 1,4-benzohinon, gde se Q odnosi na hinonsku hemijsku grupu, i 10 označava broj izoprenilnih hemijskih podjedinica u njegovom repu.

Ova u ulju rastvorna, vitaminu slična supstanca je prisutna u većini eukariotskih ćelija, prvenstveno u mitohondrijama. Ona je komponenta lanca transporta elektrona i učestvuje u aerobnoj ćelijskoj respiraciji, generišući energiju u obliku ATP-a. Devedeset pet procenata energije ljudskog tela se generiše na taj način.^[3]^[4] Stoga, organi sa najvišim zahtevom za energiju, kao što su srce, jetra i bubrezi, imaju najviše koncentracije CoQ₁₀.^[5]^[6]^[7] Postoje tri redoks stanja koenzima Q₁₀: potpuno oksidizovano (ubihnon), semihinon (ubisemihinon), i potpuno redukovano (ubihinol). Sposobnost ovog molekula da postoji u potpuno oksidovanoj formi i potpuno redukovanoj formi omogućava mu da izvodi svoju funkciju u lancu transporta elektrona i da deluje kao antioksidans.

Vidi još уреди

Idebenon

Reference уреди

^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Ernster, L; Dallner, G (1995). „Biochemical, physiological and medical aspects of ubiquinone function”. Biochimica et Biophysica Acta. 1271 (1): 195—204. PMID 7599208.
^ Dutton, PL; Ohnishi, T; Darrouzet, E; Leonard, MA; Sharp, RE; Cibney, BR; Daldal, F; Moser, CC (2000). „4 Coenzyme Q oxidation reduction reactions in mitochondrial electron transport”. Ур.: Kagan, VE; Quinn, PJ. Coenzyme Q: Molecular mechanisms in health and disease. Boca Raton: CRC Press. стр. 65—82.
^ Okamoto, T; Matsuya, T; Fukunaga, Y; Kishi, T; Yamagami, T (1989). „Human serum ubiquinol-10 levels and relationship to serum lipids”. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. 59 (3): 288—92. PMID 2599795.
^ Aberg, F; Appelkvist, EL; Dallner, G; Ernster, L (1992). „Distribution and redox state of ubiquinones in rat and human tissues”. Archives of biochemistry and biophysics. 295 (2): 230—4. PMID 1586151. doi:10.1016/0003-9861(92)90511-T.
^ Shindo, Y; Witt, E; Han, D; Epstein, W; Packer, L (1994). „Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin”. The Journal of investigative dermatology. 102 (1): 122—4. PMID 8288904. doi:10.1111/1523-1747.ep12371744.

Literatura уреди

Spoljašnje veze уреди

Detailed discussion of coenzyme q10 health benefits
Robert Alan Bonakdar and Erminia Guarneri, American Family Physician page on Coenzyme Q₁₀
An Introduction to Coenzyme Q₁₀
Possible Health Benefits of Coenzyme Q₁₀ at Oregon State University
Study Suggests Coenzyme Q₁₀ Slows Functional Decline in Parkinson's Disease at National Institute of Neurological Disorders and Stroke

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[2] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[3] Ernster, L; Dallner, G (1995). „Biochemical, physiological and medical aspects of ubiquinone function”. Biochimica et Biophysica Acta. 1271 (1): 195—204. PMID 7599208.

[4] Dutton, PL; Ohnishi, T; Darrouzet, E; Leonard, MA; Sharp, RE; Cibney, BR; Daldal, F; Moser, CC (2000). „4 Coenzyme Q oxidation reduction reactions in mitochondrial electron transport”. Ур.: Kagan, VE; Quinn, PJ. Coenzyme Q: Molecular mechanisms in health and disease. Boca Raton: CRC Press. стр. 65—82.

[5] Okamoto, T; Matsuya, T; Fukunaga, Y; Kishi, T; Yamagami, T (1989). „Human serum ubiquinol-10 levels and relationship to serum lipids”. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. 59 (3): 288—92. PMID 2599795.

[6] Aberg, F; Appelkvist, EL; Dallner, G; Ernster, L (1992). „Distribution and redox state of ubiquinones in rat and human tissues”. Archives of biochemistry and biophysics. 295 (2): 230—4. PMID 1586151. doi:10.1016/0003-9861(92)90511-T.

[7] Shindo, Y; Witt, E; Han, D; Epstein, W; Packer, L (1994). „Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin”. The Journal of investigative dermatology. 102 (1): 122—4. PMID 8288904. doi:10.1111/1523-1747.ep12371744.

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