Ubikvitin-kalmodulinska ligaza
Ubikvitin-kalmodulinska ligaza (EC 6.3.2.21, ubikvitil-kalmodulinska sintaza, ubikvitin-kalmodulinska sintetaza, ubikvitil-kalmodulinska sintetaza, uCaM-sintetaza) je enzim sa sistematskim imenom kalmodulin:ubikvitin ligaza (formira AMP).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Ubikvitin-kalmodulinska ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 6.3.2.21 | ||||||||
| CAS broj | 119632-60-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- n ATP + kalmodulin + n ubikvitin n AMP + n difosfat + (ubikvitin)N-kalmodulin
Ovaj enzim je specifičan za Ca2+-kalmodulin kod kičmenjaka.
Reference уреди
- ^ Jennissen, H.P. & Laub, M. (1988). „Ubiquitin-calmodulin conjugating activity from cardiac muscle”. Biol. Chem. Hoppe-Seyler. 369: 1325—1330. PMID 2853950.
- ^ Ziegenhagen, R. & Jennissen, H.P. (1988). „Multiple ubiquitination of vertebrate calmodulin by reticulocyte lysate and inhibition of calmodulin conjugation by phosphorylase kinase”. Biol. Chem. Hoppe-Seyler. 369: 1317—1324. PMID 2853949.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze уреди
- Ubiquitin---calmodulin+ligase на US National Library of Medicine Medical Subject Headings (MeSH)
