Ubikvitin-proteinska ligaza
(преусмерено са Ubiquitin ligase)
Ubikvitin-proteinska ligaza (EC 6.3.2.19, ubikvitin-aktivirajući enzim) je enzim sa sistematskim imenom ubikvitin:protein-lizin N-ligaza (formira AMP).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Ubikvitin-proteinska ligaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 6.3.2.19 | ||||||||
| CAS broj | 74812-49-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Ubikvitin je vezan za ovaj protein peptidnom vezom između C-terminalnog glicina ubikvitina i epsilon-amino grupa lizinskih ostataka proteina.
Reference уреди
- ^ Ciechanover, A., Elias, S., Heller, H. and Hershko, A. (1982). „Covalent affinity purification of ubiquitin-activating enzyme”. J. Biol. Chem. 257: 2537—2542. PMID 6277904.
- ^ Haas, A.L. & Rose, I.A. (1982). „The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis”. J. Biol. Chem. 257: 10329—10337. PMID 6286650.
- ^ Haas, A.L., Warms, J.V.B., Hershko, A. and Rose, I.A. (1982). „Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation”. J. Biol. Chem. 257: 2543—2548. PMID 6277905.
- ^ Hershko, A., Heller, H., Eytan, E. and Reiss, Y. (1986). „The protein substrate binding site of the ubiquitin-protein ligase system”. J. Biol. Chem. 261: 11992—11999. PMID 3017957.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- Ubiquitin-protein+ligase на US National Library of Medicine Medical Subject Headings (MeSH)
