Vetispiradienska sintaza
Vetispiradienska sintaza (EC 4.2.3.21, farnezil pirofosfatna ciklaza (formira vetispiradien), pemnaspirodienska sintaza, HVS, vetispiradienska ciklaza) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat difosfat-lijaza (ciklizacija, formira vetispiradien).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
| Vetispiradienska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.3.21 | ||||||||
| CAS broj | 192465-18-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (2E,6E)-farnezil difosfat vetispiradien + difosfat
Inicijalna interna ciklizacija proizvodi monociklični intermedijer germakren A.
Reference
уреди- ^ Back, K. & Chappell, J. (1995). „Cloning and bacterial expression of a sesquiterpene cyclase from Hyoscyamus muticus and its molecular comparison to related terpene cyclases”. J. Biol. Chem. 270: 7375—7381. PMID 7706281.
- ^ Keller, H., Czernic, P., Ponchet, M., Ducrot, P.H., Back, K., Chappell, J., Ricci, P. and Marco, Y. (1998). „Sesquiterpene cyclase is not a determining factor for elicitor- and pathogen-induced capsidiol accumulation in tobacco”. Planta. 205: 467—476.
- ^ Mathis, J.R., Back, K., Starks, C., Noel, J., Poulter, C.D. and Chappell, J. (1997). „Pre-steady-state study of recombinant sesquiterpene cyclases”. Biochemistry. 36: 8340—8348. PMID 9204881.
- ^ Yoshioka, H., Yamada, N. and Doke, N. (1999). „cDNA cloning of sesquiterpene cyclase and squalene synthase, and expression of the genes in potato tuber infected with Phytophthora infestans”. Plant Cell Physiol. 40: 993—998. PMID 10588069.
- ^ Martin, V.J., Yoshikuni, Y. and Keasling, J.D. (2001). „The in vivo synthesis of plant sesquiterpenes by Escherichia coli”. Biotechnol. Bioeng. 75: 497—503. PMID 11745124.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Vetispiradiene+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
