(С)-манделат дехидрогеназа
(S)-mandelat dehidrogenaza (EC 1.1.99.31, MDH) je enzim sa sistematskim imenom (S)-mandelat:akceptor 2-oksidoreduktaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
| (S)-mandelat dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.99.31 | ||||||||
| CAS broj | 9067-95-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (S)-mandelat + akceptor fenilglioksilat + redukovani akceptor
Ovaj enzim je član FMN zavisne familije oksidaza/dehidrogenaza alfa-hidroksi-kiselina. Svi enzimi ove familije oksidišu (S)-enantiomer alfa-hidroksi kiselina do alfa-okso kiselina. Izvor oksidansa (kiseonik, intramolekulski hem ili neki drugi akceptor) je zavistan od specifičnog enzima.
Reference уреди
- ^ Lehoux, I.E. & Mitra, B. (1999). „(S)-Mandelate dehydrogenase from Pseudomonas putida: mechanistic studies with alternate substrates and pH and kinetic isotope effects”. Biochemistry. 38: 5836—5848. PMID 10231535.
- ^ Dewanti, A.R., Xu, Y. and Mitra, B. (2004). „Role of glycine 81 in (S)-mandelate dehydrogenase from Pseudomonas putida in substrate specificity and oxidase activity”. Biochemistry. 43: 10692—10700. PMID 15311930.
- ^ Dewanti, A.R., Xu, Y. and Mitra, B. (2004). „Esters of mandelic acid as substrates for (S)-mandelate dehydrogenase from Pseudomonas putida: implications for the reaction mechanism”. Biochemistry. 43: 1883—1890. PMID 14967029.
Literatura уреди
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze уреди
- (S)-mandelate+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)
