2,5-дихидроксипиридин 5,6-диоксигеназа
2,5-dihidroksipiridin 5,6-dioksigenaza (EC 1.13.11.9, 2,5-dihidroksipiridinska oksigenaza, piridin-2,5-diolna dioksigenaza, NicX) je enzim sa sistematskim imenom 2,5-dihidroksipiridin:kiseonik 5,6-oksidoreduktaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 2,5-dihidroksipiridin 5,6-dioksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.13.11.9 | ||||||||
| CAS broj | 9029-57-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- 2,5-dihidroksipiridin + O2 N-formilmaleaminska kiselina
Za rad ovog enzima neohodan je Fe2+.
Reference
уреди- ^ Behrman, E.J. & Stanier, R.Y. (1957). „The bacterial oxidation of nicotinic acid”. J. Biol. Chem. 228: 923—945. PMID 13475371.
- ^ Gauthier, J.J. & Rittenberg, S.C. (1971). „The metabolism of nicotinic acid. I. Purification and properties of 2,5-dihydroxypyridine oxygenase from Pseudomonas putida N-9”. J. Biol. Chem. 246: 3737—3742. PMID 5578917.
- ^ Gauthier, J.J. & Rittenberg, S.C. (1971). „The metabolism of nicotinic acid. II. 2,5-Dihydroxypyridine oxidation, product formation, and oxygen 18 incorporation”. J. Biol. Chem. 246: 3743—3748. PMID 5578918.
- ^ Jimenez, J.I., Canales, A., Jimenez-Barbero, J., Ginalski, K., Rychlewski, L., Garcia, J.L. and Diaz, E. (2008). „Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440”. Proc. Natl. Acad. Sci. USA. 105: 11329—11334. PMID 18678916.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- 2,5-dihydroxypyridine+5,6-dioxygenase на US National Library of Medicine Medical Subject Headings (MeSH)
