2-Метилисоцитратна дехидратаза
2-metilisocitratna dehidrataza (EC 4.2.1.99, (2S,3R)-3-hidroksibutan-1,2,3-trikarboksilatna hidrolijaza) je enzim sa sistematskim imenom (2S,3R)-3-hidroksibutan-1,2,3-trikarboksilat hidrolijaza (formira (Z)-but-2-en-1,2,3-trikarboksilat).[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
| 2-metilisocitratna dehidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.99 | ||||||||
| CAS broj | 170780-51-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
- (2S,3R)-3-hidroksibutan-1,2,3-trikarboksilat (Z)-but-2-en-1,2,3-trikarboksilat + H2O
Enzim iz gljive Yarrowia lipolitica (Saccharomycopsis) ne deluje na izocitrat.
Reference
уреди- ^ Aoki, H., Uchiyama, H., Umetsu, H., Tabuchi, T. (1995). „Isolation of 2-methylisocitrate dehydratase, a new enzyme serving in the methylcitric acid cycle for propionate metabolism, from Yarrowia lipolytica”. Biosci. Biotechnol. Biochem. 59: 1825—1828.
- ^ Tabuchi, T., Umetsu, H., Aoki, H., Uchiyama, H. (1995). „Characteristics of 2-methylisocitrate dehydratase, isolated from Yarrowia lipolytica, in comparison to aconitase”. Biosci. Biotechnol. Biochem. 59: 2013—2017.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
уреди- 2-methylisocitrate+dehydratase на US National Library of Medicine Medical Subject Headings (MeSH)
