Дволанчана урацил-ДНК гликозилаза
Dvolančana uracil-DNK glikozilaza (EC 3.2.2.28, Mug, Dug, dsUDG, dvolančana DNK specifična UDG, dsDNK specifična UDG, UdgB, DNK glikozilaza specifična za G:T/U neusklađenost, UDG) je enzim sa sistematskim imenom uracil-dvolančana DNK dezoksiribohidrolaza (otpuštanje uracila).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
Dvolančana uracil-DNK glikozilaza | |||||||||
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Identifikatori | |||||||||
EC broj | 3.2.2.28 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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- specifična hidroliza neusklađene dvolančane DNK i polinukleotida čime se oslobađa uracil
Ovaj enzim ne deluje na DNK koja sadrži T/G neusklađenost ili jednolančanu DNK koja sadrži bilo za-mesto-specifični uracil ili 3,N4-etenocitozinski ostatak.
Reference
уреди- ^ Barrett, T.E., Scharer, O.D., Savva, R., Brown, T., Jiricny, J., Verdine, G.L. and Pearl, L.H. (1999). „Crystal structure of a thwarted mismatch glycosylase DNA repair complex”. EMBO J. 18: 6599—6609. PMID 10581234.
- ^ Sung, J.S. & Mosbaugh, D.W. (2000). „Escherichia coli double-strand uracil-DNA glycosylase: involvement in uracil-mediated DNA base excision repair and stimulation of activity by endonuclease IV”. Biochemistry. 39: 10224—10235. PMID 10956012.
- ^ Mokkapati, S.K., Fernandez de Henestrosa, A.R. and Bhagwat, A.S. (2001). „Escherichia coli DNA glycosylase Mug: a growth-regulated enzyme required for mutation avoidance in stationary-phase cells”. Mol. Microbiol. 41: 1101—1111. PMID 11555290.
Literatura
уреди- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
уреди- Double-stranded+uracil-DNA+glycosylase на US National Library of Medicine Medical Subject Headings (MeSH)