Гама-глутамилна хидролаза

Gama-glutamilna hidrolaza (EC 3.4.19.9, konjugaza, folatna konjugaza, lizozomalna gama-glutamilna karboksipeptidaza, gama-Glu-X karboksipeptidaza, pteroil-poli-gama-glutamatna hidrolaza, karboksipeptidaza G, folno kiselinska konjugaza, poli(gama-glutaminsko kiselinska) endohidrolaza, poliglutamatna hidrolaza, poli(glutaminsko kiselinska) hidrolaza II, pteroilpoli-gama-glutamilna hidrolaza) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju

Gama-glutamilna hidrolaza
Identifikatori
EC broj3.4.19.9
CAS broj9074-87-7
Baze podataka
IntEnzIntEnz pregled
BRENDABRENDA pristup
ExPASyNiceZyme pregled
KEGGKEGG pristup
MetaCycmetabolički put
PRIAMprofil
Strukture PBPRCSB PDB PDBe PDBj PDBsum
Hidroliza gama-glutamilne veze

Ova lizozomalna ili izlučena, tiol-zavisna peptidaza je najaktivnija na kiselom pH.

Reference

уреди
  1. ^ McGuire, J.J. & Coward, J.K. (1984). „Pteroylpolyglutamates: biosynthesis, degradation and function.”. Ур.: Blakley, R.L. and Benkovic, S.J. Folates and Pterins. New York: John Wiley and Sons. стр. 135—191. 
  2. ^ Wang, Y., Nimec, Z., Ryan, T.J., Dias, J.A. and Galivan, J. (1993). „The properties of the secreted γ-glutamyl hydrolases from H35 hepatoma cells”. Biochim. Biophys. Acta. 1164: 227—235. PMID 8343522. 
  3. ^ Yao, R., Rhee, M.S. and Galivan, J. (1995). „Effects of γ-glutamyl hydrolase on folyl and antifolylpolyglutamates in cultured H35 hepatoma cells”. Mol. Pharmacol. 48: 505—511. PMID 7565632. 
  4. ^ Yao, R., Schneider, E., Ryan, T.J. and Galivan, J. (1996). „Human γ-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro”. Proc. Natl. Acad. Sci. USA. 93: 10134—10138. PMID 8816764. 
  5. ^ Yao, R., Nimec, Z., Ryan, T.J. and Galivan, J. (1996). „Identification, cloning, and sequencing of a cDNA coding for rat γ-glutamyl hydrolase”. J. Biol. Chem. 271: 8525—8528. PMID 8621474. 

Литература

уреди
  • McGuire, J.J. & Coward, J.K. (1984). „Pteroylpolyglutamates: biosynthesis, degradation and function.”. Ур.: Blakley, R.L. and Benkovic, S.J. Folates and Pterins. New York: John Wiley and Sons. стр. 135—191. 

Spoljašnje veze

уреди